Dose strengths of hydrocodone/APAP start with the number of milligrams of hydrocodone and follow with the acetaminophen dose. The most commonly prescribed strength of hydrocodone/APAP is. What Is Hydrocodone/Acetaminophen and How Does It Work? What Are Dosages of Hydrocodone/Acetaminophen? What Are Side Effects Associated with Using Hydrocodone/Acetaminophen? What other drugs interact with Hydrocodone/Acetaminophen? What are warnings and precautions for Hydrocodone/Acetaminophen? Hydrocodone is a potent opioid used to manage severe and persistent pain that requires an extended treatment period with a daily opioid pain medicine, when other non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Hydrocodone bitartrate and acetaminophen tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Overview: Hydrocodone/acetaminophen is a combination medicine taken to help treat pain. Common side effects may include constipation, dizziness, drowsiness, headache, and stomach pain. Do not. Hydrocodone APAP combines an opioid with acetaminophen for pain relief, but comes with real risks. Here’s what you need to know before taking it. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage. Take hydrocodone and acetaminophen exactly as prescribed by your healthcare provider. Take your prescribed dose every four to six hours at the same time every day. Do not take more than your prescribed dose. Hydrocodone bitartrate and acetaminophen tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. When you first start taking Hydrocodone Bitartrate and Acetaminophen Tablets, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Talk to your healthcare provider about naloxone, a medicine for the emergency treatment of an opioid overdose.