Hydrocodone belongs to the group of medicines called opioid analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. Hydrocodone/Acetaminophen is a prescription medication used to treat Moderate to Severe Pain. Learn about side effects, dosages, drug interactions, and more. Hydrocodone Acetaminophen 5-325 is a widely prescribed painkiller, combining an opioid and a non-opioid analgesic. While effective for managing moderate to severe pain, its potential for misuse, dependence, and addiction raises significant concerns. Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Hydrocodone and acetaminophen is a Schedule II controlled substance. All branded hydrocodone and acetaminophen (Norco, Vicodin, Lortab, Hycet, Lorcet, Verdrocet, Xodol, Zamicet) have been discontinued, but generic hydrocodone and acetaminophen tablets and oral solution is still available. This combination medication is used to relieve moderate to severe pain. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. Hydrocodone APAP combines an opioid with acetaminophen for pain relief, but comes with real risks. Here’s what you need to know before taking it. Norco and Vicodin are prescription combination tablets that both contain the opioid hydrocodone with acetaminophen, used for moderate to severe pain. The main difference is the amount of acetaminophen in each. Hydrocodone bitartrate and acetaminophen tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.